Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1224)
Related Products (1224)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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ω-Grammotoxin SIA
0 ImagesCat. No.: HY-P2699CAS No.: 152617-90-8Synonyms: GrTx; ω-GsTx SIAω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases.
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L-Phenylalanine-d1
0 ImagesCat. No.: HY-178251SCAS No.: 55836-70-9L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
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N-Desalkylflurazepam (Standard)
0 ImagesSynonyms: Norfludiazepam (Standard)N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively.
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Landiolol-d8
0 ImagesCat. No.: HY-100607SSynonyms: ONO1101-d8Landiolol-d8 (ONO1101-d8) is the deuterium labeled Landiolol (HY-100607). Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
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HCA-6
0 ImagesCat. No.: HY-179026HCA-6 is a calcium-channel and P-glycoprotein blocker. HCA-6 can induce cancer cells apoptosis and increase anticancer activity of Cisplatin (HY-17394). HCA-6 also exhibits antibacterial activity against Bacillus subtilis. HCA-6 can be used for the research of cancer and infection, such as breast cancer.
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Iganidipine dihydrochloride
0 ImagesCat. No.: HY-101685ACAS No.: 117241-46-0Synonyms: NKY-722Iganidipine dihydrochloride is a Ca2+ antagonist.
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(S)-Albuterol hydrochloride
0 ImagesCat. No.: HY-137311CAS No.: 50293-91-9(S)-Albuterol hydrochloride is a muscarinic receptor and phospholipase C activator. (S)-Albuterol hydrochloride increases intracellular free calcium in airway smooth muscle.
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Nilvadipine-d4
0 ImagesCat. No.: HY-14284SCAS No.: 2928067-26-7Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
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(Rac)-NNC 55-0396
0 ImagesCat. No.: HY-50722ACAS No.: 2517420-92-5(Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722).
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Farnesyl pyrophosphate
0 ImagesCat. No.: HY-113037BCAS No.: 372-97-4Synonyms: Farnesyl diphosphateFarnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
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BN 50341
0 ImagesCat. No.: HY-116400CAS No.: 107550-66-3BN 50341 is an orally active anticalcic agent and a benzazepine derivative. BN 50341 decreases the in vivo electrically induced thrombus formation in rat or guinea-pig artery and can be utilized in cardiovascular research.
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(rel)-Mirogabalin
0 ImagesCat. No.: HY-12650ACAS No.: 1138244-97-9Synonyms: (rel)-DS5565(rel)-Mirogabalin ((rel)-DS5565) is a voltage-dependent calcium channel inhibitor that acts on the α2δ-1 subunit.
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Magnesium sulfate heptahydrate, for molecular biology
0 ImagesCat. No.: HY-W094477DCAS No.: 10034-99-8Synonyms: Epsom salts, for molecular biologyMagnesium sulfate heptahydrate (for molecular biology) is a molecular biology-grade form of Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a uterine contraction inhibitor. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in research on diseases such as preeclampsia/eclampsia.
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Drotaverine-d10 hydrochloride
0 ImagesCat. No.: HY-108974SDrotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects.
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(S)-Lercanidipine hydrochloride
0 ImagesCat. No.: HY-B0612ECAS No.: 184866-29-3(S)-Lercanidipine hydrochloride is the S-enantiomer of Lercanidipine hydrochloride. (S)-lercanidipine hydrochloride is a potent calcium channel blocker.
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AJ-3941
0 ImagesCat. No.: HY-165572CAS No.: 143110-70-7AJ-3941 is an orally active cerebrovascular-selective Calcium Channel antagonist having anti-lipid peroxidative action. AJ-3941 can ameliorate the brain infarction and edema after permanent focal cerebral ischemia.
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m-Nisoldipine
0 ImagesCat. No.: HY-W184837CAS No.: 113578-26-0Synonyms: KR-1008m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
